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Product Categories
Pathological antibody
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Product Name
Bcl6 Rabbit mAb
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Background
Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs).
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Alternative Names
BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51
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Immunogen
A synthesized peptide derived from human BCL6
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Dilution Ratio
IHC: 1/100-1/200
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Molecular Weight
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Gene Name
BCL6
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Host
Rabbit
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Reactivity
Human
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Conjugation
Unconjugated
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Application
IHC-P
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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SwissProt ID
P41182
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Purification
Affinity Purified
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Clonality No.
BP6216
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Clonality
Monoclonal Antibody
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Isotype
IgG
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Form
Liquid
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Research Field
Epigenetics and Nuclear Signaling
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Gene ID
604
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Modification
Unmodified